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A team of researchers from Lorraine spent several months solving the puzzle. To do so, cryptographer Cécile Pierrot, mathematician Pierrick Gaudry, computer scientist Paul Zimmermann and historian Camille Desenclos drew on other ciphered dispatches sent to the same ambassador and held at the Bibliothèque municipale de Besançon (Doubs). Fortunately, several symbols appeared in cleartext in the margins to make these dispatches easier to decipher. These valuable clues gradually helped them reconstruct the entire cipher Charles V had used in his letter. It reveals that the emperor was suspicious—wrongly—of the king of France: he suspected Francis Ist of plotting to have him assassinated.
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Extract from Charles V's letter.